MovDisordV3, Main, Exploration, bibRecord, 004A52

Internal globus pallidotomy in dystonia secondary to Huntington's disease

Identifieur interne : 004A52 ( Main/Exploration ); précédent : 004A51; suivant : 004A53

Internal globus pallidotomy in dystonia secondary to Huntington's disease

Auteurs : Esther Cubo [États-Unis] ; Kathleen M. Shannon [États-Unis] ; Richard D. Penn [États-Unis] ; Jeffrey S. Kroin [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2000-11.

RBID : ISTEX:A72A371B65EA7427FC801FC65CA8840FD20434E4

Descripteurs français

Pascal (Inist)
- Chorée Huntington, Complication, Dystonie, Enfant, Etude cas, Exérèse, Femelle, Interne, Pallidotomie, Pallidum, Réfractaire, Traitement.
Wicri :
- topic : Enfant.

English descriptors

KwdEn :
- Adolescent, Case study, Child, Complication, Dystonia, Dystonia (etiology), Dystonia (physiopathology), Dystonia (surgery), Exeresis, Fatal Outcome, Female, Globus Pallidus (surgery), Humans, Huntington Disease (complications), Huntington Disease (physiopathology), Huntington Disease (surgery), Huntington disease, Huntington's disease, Internal, Microsurgery (methods), Pallidotomy, Pallidum, Refractory, Severity of Illness Index, Stereotaxic Techniques, Treatment.
MESH :
- complications : Huntington Disease.
- etiology : Dystonia.
- methods : Microsurgery.
- physiopathology : Dystonia, Huntington Disease.
- surgery : Dystonia, Globus Pallidus, Huntington Disease.
- Adolescent, Fatal Outcome, Female, Humans, Severity of Illness Index, Stereotaxic Techniques.

Abstract

INTRODUCTION AND METHOD: The prototypic motor feature of Huntington's disease (HD) is chorea, but parkinsonism and involuntary movements such as dystonia and myoclonus can also be present. Pallidotomy has been shown to be an effective treatment for medically refractory Parkinson's disease (PD). We performed bilateral microelectrode guided‐stereotactic pallidotomies targeted at globus pallidum internus (GPi) to treat a 13‐year‐old patient diagnosed with Westphal variant of HD with intractable generalized dystonia and parkinsonism. RESULTS: Intraoperative microelectrode recordings of GPi cells showed a relatively low firing rate, 29 + 14 Hz, with most neurons showing pauses. Acutely, after surgery, limb dystonia mildly improved but trunk dystonia persisted. Postoperative follow up 3 months later showed minimal clinical improvement in dystonic features with marked worsening of spasticity. CONCLUSION: In our case, bilateral pallidotomy produced modest palliative functional improvement in dystonic features. Cellular firing patterns were markedly different than in PD and were similar to those found in dystonia.

Url:

https://api.istex.fr/document/A72A371B65EA7427FC801FC65CA8840FD20434E4/fulltext/pdf

DOI: 10.1002/1531-8257(200011)15:6<1248::AID-MDS1029>3.0.CO;2-Q

Affiliations:

Le document en format XML

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<term>Complication</term>
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<term>Dystonia (etiology)</term>
<term>Dystonia (physiopathology)</term>
<term>Dystonia (surgery)</term>
<term>Exeresis</term>
<term>Fatal Outcome</term>
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<term>Huntington Disease (physiopathology)</term>
<term>Huntington Disease (surgery)</term>
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<term>Huntington Disease</term>
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<term>Severity of Illness Index</term>
<term>Stereotaxic Techniques</term>
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<term>Complication</term>
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<term>Etude cas</term>
<term>Exérèse</term>
<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">INTRODUCTION AND METHOD: The prototypic motor feature of Huntington's disease (HD) is chorea, but parkinsonism and involuntary movements such as dystonia and myoclonus can also be present. Pallidotomy has been shown to be an effective treatment for medically refractory Parkinson's disease (PD). We performed bilateral microelectrode guided‐stereotactic pallidotomies targeted at globus pallidum internus (GPi) to treat a 13‐year‐old patient diagnosed with Westphal variant of HD with intractable generalized dystonia and parkinsonism. RESULTS: Intraoperative microelectrode recordings of GPi cells showed a relatively low firing rate, 29 + 14 Hz, with most neurons showing pauses. Acutely, after surgery, limb dystonia mildly improved but trunk dystonia persisted. Postoperative follow up 3 months later showed minimal clinical improvement in dystonic features with marked worsening of spasticity. CONCLUSION: In our case, bilateral pallidotomy produced modest palliative functional improvement in dystonic features. Cellular firing patterns were markedly different than in PD and were similar to those found in dystonia.</div>
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<name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M." last="Shannon">Kathleen M. Shannon</name>
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Movement Disorders (revue)

Internal globus pallidotomy in dystonia secondary to Huntington's disease

Internal globus pallidotomy in dystonia secondary to Huntington's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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